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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS1
All Species:
34.24
Human Site:
Y466
Identified Species:
50.22
UniProt:
Q01581
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01581
NP_001091742.1
520
57294
Y466
D
E
K
H
R
R
T
Y
A
R
R
P
T
P
N
Chimpanzee
Pan troglodytes
XP_517780
610
66491
Y556
D
E
K
H
R
R
T
Y
A
R
R
P
T
P
N
Rhesus Macaque
Macaca mulatta
XP_001090857
592
65050
Y538
D
E
K
H
R
R
T
Y
A
R
R
P
T
P
N
Dog
Lupus familis
XP_536483
637
69021
Y583
D
E
K
H
R
R
T
Y
A
R
R
P
S
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZK9
520
57550
Y466
D
E
K
H
R
R
T
Y
A
R
R
P
F
T
N
Rat
Rattus norvegicus
P17425
520
57415
Y466
D
E
K
H
R
R
T
Y
A
R
R
P
S
T
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506375
520
57160
Y467
D
E
K
H
R
R
T
Y
A
R
R
P
L
P
N
Chicken
Gallus gallus
P23228
522
57541
Y467
D
E
K
H
R
R
T
Y
A
R
R
P
V
M
G
Frog
Xenopus laevis
NP_001087380
520
57303
Y467
D
E
K
H
R
R
F
Y
A
R
S
S
L
M
R
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
R454
R
V
D
E
K
H
R
R
Q
Y
A
R
R
S
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
S412
K
V
A
P
E
Q
F
S
A
L
M
E
V
R
E
Honey Bee
Apis mellifera
XP_397202
453
50855
Q400
K
Q
Q
L
D
A
R
Q
K
I
S
P
A
D
Y
Nematode Worm
Caenorhab. elegans
P54871
462
51397
R409
F
T
E
T
L
Q
K
R
E
V
F
L
R
S
K
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
L451
P
Q
G
S
I
E
D
L
F
P
G
T
W
Y
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
K408
E
K
F
V
E
T
M
K
L
M
E
H
R
Y
G
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
T438
N
K
L
A
K
R
I
T
E
T
P
K
D
Y
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
87.3
78.6
N.A.
94.6
94.8
N.A.
90.1
83.9
80
77.6
N.A.
58
54.6
38.4
63.2
Protein Similarity:
100
85
87.3
80.5
N.A.
97.5
97.6
N.A.
95.3
91
88.6
87.1
N.A.
69.6
68.6
54.8
75.3
P-Site Identity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
93.3
80
60
0
N.A.
6.6
6.6
0
0
P-Site Similarity:
100
100
100
100
N.A.
86.6
93.3
N.A.
93.3
80
60
6.6
N.A.
13.3
20
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
44
45.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.1
60.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
0
7
0
0
63
0
7
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
57
0
7
0
7
0
7
0
0
0
0
0
7
7
0
% D
% Glu:
7
57
7
7
13
7
0
0
13
0
7
7
0
0
13
% E
% Phe:
7
0
7
0
0
0
13
0
7
0
7
0
7
0
0
% F
% Gly:
0
0
7
0
0
0
0
0
0
0
7
0
0
0
13
% G
% His:
0
0
0
57
0
7
0
0
0
0
0
7
0
0
0
% H
% Ile:
0
0
0
0
7
0
7
0
0
7
0
0
0
0
0
% I
% Lys:
13
13
57
0
13
0
7
7
7
0
0
7
0
0
7
% K
% Leu:
0
0
7
7
7
0
0
7
7
7
0
7
13
0
7
% L
% Met:
0
0
0
0
0
0
7
0
0
7
7
0
0
13
7
% M
% Asn:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
38
% N
% Pro:
7
0
0
7
0
0
0
0
0
7
7
57
0
32
0
% P
% Gln:
0
13
7
0
0
13
0
7
7
0
0
0
0
0
0
% Q
% Arg:
7
0
0
0
57
63
13
13
0
57
50
7
19
7
7
% R
% Ser:
0
0
0
7
0
0
0
7
0
0
13
7
13
13
7
% S
% Thr:
0
7
0
7
0
7
50
7
0
7
0
7
19
13
0
% T
% Val:
0
13
0
7
0
0
0
0
0
7
0
0
13
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
0
0
0
0
0
0
0
57
0
7
0
0
0
19
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _